Dope vitality and sets up the moral! What were we waiting for?

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Smiley at happytherapy.com

I first encountered a reference to Smiley aromatherapy products in Jane magazine, which raves in typical Jane-ish style:

Tech-y jargon aside, the scientists behind this blew right on past aromatherapy by isolating scentless molecules that react in your brain to “activate happiness” – then they threw them in yummy-smelling body stuff.

To me, it sounded like the Smiley “scientists” blew right on past science. So I checked out the website, www.happytherapy.com. According to the site (a native english speaker needs to join the staff, pronto):

In order to have everyone smile, even the most stubborn, smiley entrusted science with the composition of an olfactive substance with euphoriant bio-mechanics. It is in nature that the components of this psycho-active cocktail were drawn. Thanks to research undertaken worldwide by scientists on the tangible benefits of aromatherapy, Smiley isolated the ingredients recognized for their stimulating capacities and assembled them for the first time in a perfume.

Smiley contains monoaminated alkaloids having a pharmacodynamic action called phenylethylamine and theobromine. Phenylethylamine is to passion what endorphin is to love. It sets off a feeling of joy, excitement and euphoria. Theobromine blocks the receivers of adrenalin and thus decreases the effects of stress by a comfortable feeling of wellbeing. These two cardiotonics associated together dope vitality and sets up the moral. It’s that simple! What were we waiting for to flood these beneficial molecules on everyone?

Good question.

Basically, they claim the happy-making effects of the products are mediated by PEA and theobromine. So why not just eat some chocolate? Theobromine, a cousin of caffeine, is found almost exclusively in chocolate (although chocolate is commonly thought to be full of caffeine, milk chocolate actually has little caffeine relative to theobromine). PEA, a naturally occurring neurotransmitter in our brains, is also found in chocolate. Although the evidence isn’t overwhelming, some people think cravings for chocolate may be a form of self-medication for slight depression.

But chocolate is a complex cocktail. In addition to PEA and theobromine, it also has anandamide, various alkaloids, and tyramine. There’s a lot going on in a chocoholic’s brain, and it’s unclear if the same effects would result from the lotions, self-tanners, deodorants, and perfumes in the smiley line. Can PEA and theobromine be absorbed cutaneously at effective levels? I have no clue (according to wikipedia, PEA is actually a skin irritant with a fishy odor. . . ).

And the texture and flavor of chocolate add significantly to the pleasure of eating it. I had a mindbogglingly good chocolate mousse on Friday and I was in seventh heaven; the nutella wrapped in pizza dough that followed was a major let-down. Both chemically chocolate, but hardly equal in pleasure.

Incidentally, since theobromine is what makes chocolate toxic to dogs (they metabolize it more slowly than we do), dog owners should keep these products safely in the medicine cabinet. Or just eat some chocolate instead. I think I will.

PS. Update: Retrospectacle has a post on caffeinated soap – a similar idea. Supposedly it works, but I don’t think I’ll be trying it.

Posted in Biology, Frivolity, Science | 2 Comments

Half a million buys a lot of bones

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Mammoth skeleton sets auction record – Boston.com

On Monday, a rare Siberian mammoth skeleton sold for nearly half a million dollars at auction. The skeleton was inexplicably named “The President.”

A number of other curiosity-cabinet staples, like a bezoar, also sold, racking up a total of $1.5 million. The auction is a sign of increasing interest in natural history collectibles. Scientists complain such specimens shouldn’t be sold to private collectors, where they become inaccessible to researchers, but at these prices museums can’t compete. And as with early 20th century art, it seems provenance problems follow skyrocketing prices. A Russian official has challenged the origin of auctioned fossils.

PS. The first line of the Wikipedia article I linked for bezoar is perfectly indicative of the Wikipedia accessibility problem:

“A bezoar or enterolith is a sort of calculus or concretion, a stone found in the intestines of mostly ruminant animal.”

Oh, of course. I’m sure everyone gets it now. It’s something to do with math!

Posted in Biology, Museum Lust, Science, Wonder Cabinets | 2 Comments

Medical school unloads more art

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Portrait of Benjamin H. Rand
Thomas Eakins, 1874

This time around, there wasn’t much controversy.

The Philadelphia medical school that sold Thomas Eakins’ The Gross Clinic has now sold a second Eakins from its collection, Portrait of Benjamin H. Rand. The painting was sold to the Crystal Bridges Museum of Bentonville, AK (NYT report). The still-unbuilt museum was thwarted in its bid to buy The Gross Clinic by a consortium of local groups determined to see the historic painting stay in Philadelphia. Apparently Crystal Bridges really wanted an Eakins, and settled for the lesser-known Portrait.

What makes these sales sad is that the paintings are not merely owned by Thomas Jefferson University, they’re part of its history. Eakins studied there; both paintings depict faculty at the university’s medical school. Like a modest home that appreciates beyond its retired owners’ dreams, becoming an unwelcome tax burden, the Eakins paintings have become too valuable to keep. In selling them, and in planning to sell its third and last Eakins, the university claims to be raising desperately needed funds for educational purposes – implying that art isn’t educational, or that it is proportionately less educational than medical equipment. It’s unfortunate that they have to choose.

Posted in Artists & Art, Museum Lust | Comments Off

How NOT to write a science book

Cognitive Daily has a funny post on “how NOT to write a science book.”

Incidentally, for those of you who avoid science books precisely because of the problems Dave bemoans, consider trying the Best Science Writing and Best Science and Nature Writing series. They’re collections of the best science-related essays from publications like the New Yorker, Wired, etc., and they’re generally excellent tutorials on how TO write science.

Posted in Books, Science | Comments Off

Ouch, ouch, ouch

A very nice video of childbirth by the animators at Nucleus Medical Art. It shows the way the baby turns as it exits the mother’s pelvis. I would, however, watch it with the sound off, since – at least for me – classical music doesn’t make it any less painful, and just seems a little weird.

Via biosingularity

Posted in Artists & Art, Biology, Film, Video & Music, Science | Comments Off

I hear such different accounts of you as puzzle me exceedingly

So Odd a Mixture: Along the Autistic Spectrum in ‘Pride and Prejudice':

Perhaps it is high-functioning autism or Asperger’s Syndrome that provides an explanation for some characters’ awkward behaviour at crowded balls, their frequent silences or their tendency to lapse into monologues rather than truly converse with others.

Ok, I think this is a serious claim that Mr. Darcy has Asperger’s.

Excuse me, but when did personality become pathology? There’s nothing clinically wrong with Darcy – he just doesn’t like frivolous balls populated with airheads, and if he’s slightly self-occupied, it’s probably because he’s the cleverest one around. Who wouldn’t lapse into a silence or a monologue when forced to make conversation with Bingley?

According to a Yahoo story, the author also thinks Lydia has ADD.

Via Serendipities

Posted in Books | 2 Comments

Physicians are not biologists (especially in church)

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Alba, The GFP Bunny (www.ekac.org)
Photo: Chrystelle Fontaine

Happy Easter. I’m flying coast-to-coast all day today. When I finally decided to book my tickets a few days ago, I was astonished at the availability of last-minute flights. It took me a full day to realize it’s probably because today is Easter. Duh.

Honestly, Easter has never been big in my family. Most of my friends don’t celebrate religious holidays either; if they do, they secularize them. In fact, I find the safest assumption about new friends/acquaintances of my generation is that they’re agnostic or atheist. Obviously most Americans, even most Americans our age, are not atheists. But most of my friends are overeducated, dragging around those pesky MAs and PhDs. Does overeducation explain the lack of faith? And if so, can you blame this lack on atheist professors?

This Michigan Daily article notes that 1 in 5 faculty members are atheists (as opposed to 7% of the general population). Note – that’s still a minority. But the article contrasts faculty with health care professionals, who are also highly educated, but much more likely to be religious, and suggests an intriguing hypothesis:

The authors of the UCLA survey also analyzed religiosity by subject area. Not surprisingly, biological sciences had the highest incidence of atheism, while the humanities had one of the lowest. However, the profession with the very fewest atheists turned out to be health care.

Technically, medicine and biology are similar fields. However, in terms of a day job, they’re completely different. Could the academe factor in the impersonal of the biologist sitting behind a microscope account for the lack of religiosity? Is there more of that subtle, incomprehensible “real life” factor in treating and caring for people in the health professions and hence greater religiosity?

In my limited experience, this correlation is true – doctors and nurses tend to be religious, while biologists aren’t. Yet as a former professor of anatomy and physiology who taught both pre-meds and nursing students, I’ve wondered which comes first: the chicken (faith) or the egg (a medical career). For that matter, I have no idea if faith is the chicken or the egg, but enough about my poorly chosen, Easter-themed metaphor. I don’t agree with what the article suggests: that biology and medicine are very similar in the first place.
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Posted in Biology, Education, Science | 17 Comments

Poem of the Week: After rain

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Bearded Iris After Rain, 2006

In the garden at my old house, these iris are just waking up; I won’t see them in bloom this year, but it’s enough to know they’re there. I feel that way about nature in general: it is an immense comfort to know it is there. Even under the black tar-seal of an airport runway, there are fossils, and soil, and long-dormant seeds and spores that will probably outlive us all. Bless them.

“Lingering in Happiness”
Mary Oliver, Why I Wake Early: New Poems

After rain after many days without rain,
it stays cool, private and cleansed, under the trees,
and the dampness there, married now to gravity,
falls branch to branch, leaf to leaf, down to the ground

where it will disappear—but not, of course, vanish
except to our eyes. The roots of the oaks, will have their share,
and the white threads of the grasses, and the cushion of moss;
a few drops, round as pearls, will enter the mole’s tunnel;

and soon so many small stones, buried for a thousand years,
will feel themselves being touched.

Posted in Poetry | 2 Comments

A drug patent standoff in Thailand

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Image source: UNESCO (visit site for higher-res image)

This week, Patent Baristas have an excellent (as usual) post on Abbott Labs’ ongoing conflict with the government of Thailand. This unfortunate situation illustrates some key difficulties in getting expensive pharmaceuticals to impoverished populations. It’s tough when public health and free enterprise collide – it sometimes makes me glad that I’m just a biologist.

Over half a million Thai citizens are HIV-positive – in a country of 65 million, that’s about 1 in 100. The Thai government supplies about 80,000 AIDS patients with subsidized anti-retroviral drugs, including Abbott’s Kaletra. The problem is that the Thai government doesn’t want to pay full price for Kaletra to Abbott. So Thailand issued a compulsory license in January, allowing them to buy a generic version of Kaletra, probably to come from an Indian manufacturer.

A generic manufacturer will sell Kaletra to the Thai government more cheaply than Abbott will – partly because Abbott bears the original cost of research and development on the drug (as well as its ill-fated cousins – most drugs that undergo R&D don’t make it, and the company must recoup the costs of those failed drugs somewhere). The Thai government will save money (about $24 million a year); Abbott, on the other hand, will lose the Thai market – and because it’s difficult to prevent shipments of generic drugs from illicitly entering the global market, Abbott may lose sales of Kaletra in markets outside Thailand as well.

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Posted in Biology, Science | 7 Comments

Can the Darwin fish be improved upon?

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Darwin fish cladogram by Anne Casselman, Inkling Magazine

Matthew Bettelheim at Inkling Magazine has written a brief history of the Darwin fish and its various spin-offs. I had no idea there were so many.
Update: they’ve just announced a contest to design (intelligently, natch) the next Darwin fish morph. I’d enter, but Shane McKee already has my vote. (Actually, I don’t get to vote – the judges are PZ Myers, Bobby Henderson, and Nona Williams. But fish #11 rocks).

Posted in Frivolity | 1 Comment