Of Money and Science: Two Book Reviews

Paula Stephan’s observation that “not all science is created equal when it comes to funding” will not surprise any researcher who ever labored over a grant. Drugmonkey’s blog is a particularly good source of insight into how the NIH grant process works; given the importance of public funding to basic science, life science has been fortunate in receiving a disproportionate share, and arguably more than its fair share (depending on who you ask) of public money. Part of the drive to fund basic research comes out of an oft-repeated fear that the US is falling behind in the production of scientists and engineers. Yet we all know that there are not enough jobs for PhDs, insufficient funding for public universities (which then hike tuition), and PhDs have trouble transferring into jobs outside academia even as they lose interest in academic careers, especially women, who are disproportionately likely to drop out of the tenure chase. What is going wrong?

I was attracted to Paula Stephan’s book, How Economics Shapes Science, because all of these questions are at least partly about money: who gets it, for what, how it is allocated, how much a scientist can make relative to other fields. In my experience, few young scientists actually think about the financial big picture: they know that NIH and NSF and nonprofit funding organizations like HHMI are big pots of money, but they don’t necessarily know which areas get the most, or why, or how that translates into career prospects. But that’s important information for grad students and postdocs to have, not so you can go straight for the big bucks (I’m pretty sure you wouldn’t be in science, if that was your goal), but so you have a sense of what the funding prospects might be down the road when you’re seeking your first RO1, and so (especially if you are in a position to change things!) you understand the policies and structures that control science funding.

Stephan’s book is a sort of primer on all of this, and as such, likely to be quite valuable as a reference. Much of the blogospheric debate about research, education, and policy ends up decoupled from actual numbers – quite understandably, since bloggers don’t have editors and hardly have time to go looking up references. But it’s unfortunate that as a result, debates about grants and graduate programs aren’t necessarily tied to the mechanics of funding. This book may not tell you anything you don’t sense to be true already, but it offers a good grounding in the numbers that add up to national science policy, and it does so in a most accessible way.

Unfortunately, the clarity and accessibility of Stephan’s book are not shared by Philip Mirowski’s Science-Mart: Privatizing American Science, a book that boldly describes itself on its own flyleaf as “trenchantly analyzing the rise and decline in the quality and character of science in America since World War II.” Mirowski is interesting and provocative, and ultimately it is also a very good book for scientists to read. But I think his book is marred for a wide audience by two off-putting moves.

First, Mirowski’s book opens with the weirdly strained perspective of “intrepid academic researcher Viridiana Jones,” who is “strung out between the Scylla of Disneyfication of higher education and the Charybdis of Free EnronPrise in securing a patron, any patron, to support her inquiries in an era of impending financial doom.” Jones proved to be such an annoying caricature that I found it impossible to finish the first chapter of the book. I don’t think Mirowski intends Jones to be more than a fun frame for his argument; he’s not writing fiction, Jones does not narrate the book, and granted, Jones is a more creative frame than Stephan uses. (I hope my distaste for Jones doesn’t indicate I’m totally devoid of creativity at this point.) However, I personally found it annoying to be immediately confronted with a fictitious researcher, many of whose reactions were jarringly dissonant with my own, as a stand-in for my/scientists’ perspective. Harrumph.

Second, Mirowski is both trenchant and highly theoretical. I, for one, have a knee-jerk skepticism anytime a writer becomes trenchant about science, and as a result, I found it hard to appreciate that I actually agreed with many of the things Mirowski was saying, I just was having trouble piercing his tone and jargon. As an example of jargon, he (derogatorily) uses the term “neoliberal” throughout his book, but he is not using it in the political sense non-economists may first assume. A quote from a favorable review by Sheldon Krimsky may help:

The term neoliberal, which arises from the work of post–World War II economists such as Friedrich Hayek, Milton Friedman and others belonging to the “Chicago school” of economics and law, has little in common with what is usually thought of as liberalism. The important tenets of neoliberalism, Mirowski says, include such propositions as the following: “The Market” is a better processor of information than the state; “politics operates as if it were a market”; “corporations can do no wrong”; “competition always prevails”; the state should be “degovernmentalized” through “privatization of education, health, science and even portions of the military”; a good way to initiate privatization is to redefine property rights; “the nation-state should be subject to discipline and limitation through international initiatives”; “the Market . . . can always provide solutions to problems seemingly caused by markets in the first place”; “there is no such thing as a ‘public good’”; “freedom” means economic freedom within the Market.

My main complaint is not that Mirowski is right or wrong about neoliberal economics; I’m not an economist, and heck if I know. But his book is not fashioned to be readily accessible to those readers who have not had a grounding in economic theory, which I assume includes many scientists like myself. I ran across his book while reading about Schumpeter, antitrust, incentives for industrial R&D, and IP law — none of which were subjects I ever considered in graduate school — and if it weren’t for those discussions I’d have been quite lost.

Mirowski does give his readers a basic overview of economic history/theory. But Mirowski’s book is not as friendly to skimming and dipping in here and there as Stephan’s, unless you have that grounding. Statements like “there were many other examples of neoliberal interventions in the ‘knowledge economy’” and “the neoliberal is content to render the average citizen ignorant” are not readily unpacked in either tone or content without linearly following Mirowski’s trenchant narrative (which is humorous since he thinks the linear model of science is off base). Anyway, I don’t mean to suggest Mirowski is an economic apologist: his first chapter is about how ineffective economists have been at explaining and theorizing science, he then criticizes science policy wonks for getting too cozy with economists, and argues that the foundations of the science funding edifice Stephan describes may not be as solid as the rhetoric of post-cold-war policy would suggest. So perhaps stack “iconoclast” on top of trenchancy. (If you like a good flamewar, this book should feel quite homey.)

A major focus of Mirowski’s book is that as a result of patents (post-Bayh-Dole), academic science has no choice except to mimic business, to the detriment of the knowledge it produces. This is a presumption I encountered repeatedly in law school, and I believe it’s flawed as a way of predicting how individual scientists act; in my experience, most scientists are far more interested in reputation and publishing and tenure as incentives than they are in the monetization of their inventions. Also, the allure and practicality of monetization varies dramatically depending on the scientific field. However, Mirowski’s critique of Big Science has merit, because any picture of academic science is plainly incomplete without considering the university tech transfer office seeking to assert patents whether or not the PI is particularly interested, or the postdoc seeking a patent because she’s realized there is no way in heck she wants to be a PI, and she’d like to spin off a startup, or the possible problems patents pose to experimentation (particularly clinical). Just this week, a geoengineering experiment was cancelled because some of the scientists involved had filed for patents on related technology. It’s getting harder and harder to separate commercial research and academic research.

I am far from qualified to say if Mirowski is right about academic science. But his critiques are cogent, he’s witty (ignoring Viridiana, he has lots of clever snarkiness in his own voice), and if you have the patience to really dig in, it is a very provocative book.

Mirowski’s book also does very different things than Stephan’s book, even though it is on some level about the same set of issues. The best aspect of Mirowski’s book may be that it lifts the curtain on a very important debate taking place largely outside academic science, in law and economics and, to some extent, in science policy. Many, many debates about how science should be funded, structured, and rewarded do not take place within the scientific community. It’s unfortunate, as scientists have much to contribute — such as what they find to be effective incentives, why they do or don’t pursue patentable research goals, whether they are hindered in their work by patents, and how they think courts ought to look at scientific testimony or intellectual property protections. So as with Stephan’s book, I think this is well worth consideration for the summer reading list — even though it’s a bit heavy for the beach.

More:
Stephan’s How Economics Shapes Science (amazon)
Mirowski’s Science-Mart: Privatizing American Science (amazon)

Posted in Biology, Book reviews, Books, Conspicuous consumption, Education, Littademia, Science, Science in culture & policy | Comments Off

Coin-operated morticians are not easy to find

Just in case you’ve always wanted a vintage coin-operated morgue diorama with clockwork morticians and mourners, you are totally in luck! Thanks, Morbid Anatomy!

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Histology-Inspired Artist of the Day: Andrea Offerman

Andrea Offerman‘s intricate pen and ink drawings are some hybrid of children’s book illustrations and Hieronymous Bosch-ian anatomical panoramas. Andrea says,

I was always interested in art but hesitant to make it my profession. I studied medicine for a few years and was fascinated especially by anatomy and histology (microscopic anatomy of cells and tissues); the intricate ways in which a body is put together and functions, the solutions nature comes up with to ensure certain processes, and the beauty within the patterns and networks that make everything happen surprised me. That fascination is still there. My love for the organic and an interest for evolutionary and scientific themes always play a part in my work. (source: Don’t Panic)

I guess that explains what looks like people picnicking and climbing around on a long strip of partly dissected dragon!

I’ve been asked a few times whether it’s worth leaving science to do art, and although I haven’t done it myself and can’t speak to it, apparently Andrea’s quite happy with her choice to abandon medical school for art school. Read the rest of Andrea’s interview at Don’t Panic, and another interview at Juxtapoz.

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Is Starry Night the discovery, or the experiment?

Maria Popova quotes Neil DeGrasse Tyson on the difference between originality in science and in art:

If I discover a scientific idea, surely someone else would’ve discovered the same idea had I not done so. Whereas, look at Van Gogh’s “Starry Night” — if he didn’t paint “Starry Night,” nobody’s gonna paint “Starry Night.” So, in that regard, the arts are more individual to the creative person than a scientific idea is to the one who comes up with it — but, nonetheless, they are both human activities.

Hmmm. I don’t think that’s a helpful way of putting it. Van Gogh wasn’t trying to discover or capture “Starry Night,” the painting. He was trying to discover or capture something intangible by painting Starry Night: a particular aspect of motion, or light, or vastness, or awe, or silence, or delight: who knows? But the painting is the vehicle for the discovery, not the discovery itself; the painting is an experiment, an approximation, a model. And experiments, approximations, and models are personal expressions of a given scientist’s experience and worldview, as well as their historical and cultural context.

Each scientist arrives at a discovery through his or her own circuitous, and original, path. Neither the fact that the natural phenomenon they seek to describe and represent is not “original,” nor that someone else would have gotten there by a different path, should devalue that individual path — any more than the fact that the emotion of delight is not original to, nor solely elicited by, Starry Night should devalue the painting.

Artists certainly have much more room for creativity in their paths than scientists do. But speaking of originality in one vs. originality in the other is to me a red herring, inviting the wrong sorts of comparisons: we shouldn’t expect science to be exactly like art, or exactly not like art. And while I love all the science-art crosstalk going on, sometimes I feel it’s a little too tempting to make analogies that aren’t all that helpful.

But anyway, speaking of Starry Night. . .

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Of satellites, maps, and worldbuilding

It’s kind of mind-boggling how much technology has changed our relationship with maps over the past decade. I remember when my mental approximation of geography was based either on (depending on the appropriate scale) globes with pastel continents on them, Mercator projections, or road atlases. While those primitive geospatial approximations still have utility in certain contexts — and retain a certain retro chic, of course — satellite imagery is pretty much the basis for every map we encounter in our daily lives. (Most of us never have the pleasure of turning the hefty pages of 6-foot-tall atlases). Since Google Maps isn’t exactly. . . aesthetic . . . most of the time (although it can be, if you browse it on a large enough screen) it’s nice to have things like this now and then:

It’s hypnotic, isn’t it? (via It’s Okay to Be Smart).

Of course there’s one area in which old-fashioned maps haven’t been supplanted by satellite imagery: maps of fictional lands. (Here are a few, including some of my favorites — the awesomely unrealistic maps of L. Frank Baum’s Oz — and here is a tumblr.)

I was completely obsessed with fantasy maps as a child; many an original fantasy saga of mine made it to the map stage, which of course required fairly well-developed history, politics, religion, climate, language, and culture (in one case I wrote a whole illustrated encyclopedia), then petered out as I put off the chore of writing a plot because it just seemed so much less rewarding. There’s actually a word for this activity – worldbuilding – which makes it sound much more respectable than what it was in my case: “I’m motivated more by visuals than by text and my attention span is way too short to write a whole trilogy.” I think my attraction to worldbuilding is hardly unusual among fantasyphiles.

Anyway, I will say no more about fictional maps because Nicholas Tam has written an absolutely wonderful essay on the topic, covering the worlds of Tolkien, Faulkner, Baum, Jordan, and many more.

Continue reading

Posted in Artists & Art, Data Visualization, Littademia, Maps, Retrotechnology | Comments Off

Elizabeth Turk’s marble sculpture

Inspired by gravity, space, decay, and natural forms (from schools of fish to murmurations) sculptor Elizabeth Turk’s marble sculptures resemble skeletons or corals. They’re particularly lovely when she takes them to the shore and lets the waves crash on them.

The only problem is . . . well, some of the ribbonlike sculptures look like tapeworms to me. (I know, I know. It’s an ex-biologist problem. . .)

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Miscellaneous Links

A beautiful visualization of ocean currents

Pictures of math: a tumblr of science/math visualizations

And for those of you following such things, Myriad (the gene patent case) is remanded for reconsideration in light of the Supreme Court’s decision in Prometheus: NYT, GEBN, Patent Docs, Patently-O. And a very interesting passage from the last post on Prometheus:

The first critical mistake is the Court’s assumption that Prometheus’ [diagnostic test] claims recited a “law of nature:” “The claims purport to apply natural laws describing the relationships between the concentration in the blood of certain thiopurine metabolites and the likelihood that the drug dosage will be ineffective or induce harmful side-effects.” The facile assumption that this relationship is a “law of nature” is incorrect, and potentially the most damaging misstep by the Court.

First, let us assume for the moment that there are in fact such things as “laws of nature.” What would their characteristics be? A first approximation would suggest that a law of nature is immutable and universal, that it is not subject to change, and it applies in all circumstances. See, Evidence Based Science. Thus, gravity and the speed light apply to you and me equally, and under all conditions. (I’m purposely using these two examples, for reasons that will become clear.) However, this is not the case with the toxicity of any drug, including thiopurines, as acknowledged by the Court: the amount of a toxic dose varies between individuals for two reasons. First, different people metabolize at different rates, thereby producing different metabolite levels for a given dose. Second, individuals have differential responses to a given amount of the metabolites; a given level of the metabolites may be toxic in one person and not toxic in another. . . .

This relationship is a byproduct of human (or perhaps more generally mammalian) biology, which from a logical point of view is a contingent relationship that could have been otherwise: we could have evolved in such a way that the toxicity range was higher or lower, or the drug was entirely ineffective. That is, it’s an arbitrary and contingent fact that humans evolved so that thiopurine drugs were effective at all for treating immune-mediated gastrointestinal disorders, or that we metabolize them in a manner that makes them toxic at specific dosing ranges. Indeed, given that humans are not exposed to thiopurine in nature, it is hard to understand how it can even be argued that it is a “natural law” that these drugs have a specific range of toxic or effective dosages at all.

No comment.

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Free book: Gina Kolata’s Rethinking Thin

If you’d like a good used hardback copy of Gina Kolata’s Rethinking Thin, which I think is quite a good book about the science of weight loss, I will mail it to you for free.* :) Email me with your address.

*Continental US addresses only, sorry – I can’t afford to send packages abroad right now.

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Sciencedebate 2012: Should this be the top question for the next President?

You can vote for the science questions you’d most like the presidential candidates to answer, and add your own questions, here:

We’re not interested in quizzing candidates on the 4th digit of pi or the particulars of cell mitosis. We want to know their positions on the big science and engineering policy questions that affect all our lives. The questions we will consider most successful will probe the candidates on the important issues of our day around science.

The current top question is If scientific findings contradict the Bible which do you disregard? Personally, I don’t love this question – it implies that a President can’t be religious if he/she is pro-science. And I would rather avoid that impasse and seek common ground on scientific issues like climate change, to the extent that is possible. Whether you disagree or agree, consider taking a position at Sciencedebate.org.

Submit a questions for the candidates to ScienceDebate.org

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Lunch Break: The Constructal Law

I’ve been reading a book called Design in Nature, by Adrian Bejan and J. Peder Zane. It’s an extremely thought-provoking book and I haven’t fully decided what I want to say about it, so my review is still coming, but I wanted to give you a heads up that today at noon, Adrian Bejan (who is a professor of mechanical engineering at Duke) will be talking about the book and its central theme: the “constructal law,” which is sort of a unified theory for design in nature*:

Both the natural and human worlds are constantly in flux, from changing weather patterns to buzzing insects to information traveling on the Internet. Duke Professor Adrian Bejan has a theory that he says unites all such things under a single principle. His constructal law of nature explains why particles, animals and people evolve patterns — such as riverbeds, wings and highways — to move about the earth. In a live, online “Office Hours” conversation March 22, he will take viewer questions about the science behind this design in nature.

You can submit questions for Bejan before today’s webcast by email (live@duke.edu) or Twitter #dukelive.

More: Nature review of Design in Nature (firewalled, sorry)
Design in Nature at Amazon.com

*Bejan makes very clear in his book that he is talking about design principles and physics, NOT Intelligent Design. It’s kind of alarming that when scientists use the word “design” now they have to include that qualifier.

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Posted in Book reviews, Books, Design, Education, Film, Video & Music, Science, Web 2.0, New Media, and Gadgets | Comments Off